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B-Complex Vitamins (B1, B2, B3, B5, B6, B12, Folate) Serve as cofactors in mitochondrial energy pathways, supporting the conversion of macronutrients into ATP

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Oxidative stress has been implicated in the pathophysiology of cancer: in fact, high levels of ROS generated by ongoing aerobic glycolysis followed by pyruvate oxidation in mitochondria (the Warburg effect), increase receptor and oncogene activity, and the stimulation of growth factor-dependent pathways or oxidizing enzymes induce genetic instability 3,4